The mechanism of action of antimony remains unclear. It is possible that antimony affects circulating glucose by interfering with enzymes of the glycogenolysis and gluconeogenesis pathways. The inhalation data suggest that the myocardium is a target of antimony toxicity. Route of Exposure: Inhalation (L741) oral (L49) dermal (L741).A physician may need to examine the area if irritation or pain persists. Following dermal exposure, remove contaminated clothing and wash exposed area thoroughly with soap and water. In case of eye exposure, irrigate exposed eyes with copious amounts of room temperature water for at least 15 minutes. Treat bronchospasm with inhaled beta2 agonist and oral or parenteral corticosteroids. Administer oxygen and assist ventilation as required. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Following inhalation exposure, move patient to fresh air. Treatment: Following oral exposure to antimony, administer charcoal as a slurry (240 mL water/30 g charcoal). Antimony potassium tartrate skin#Skin or eye contact can cause pain and redness of the exposed surface. Dyspnea, headache, vomiting,cough, conjunctivitis, and bloody purulent discharge from nose can result from inhalation exposure. Symptoms: Abdominal pain, vomiting, diarrhea can result from inhalation of antimony.Cerebral oedema, coma, convulsions, and death are possible. Myocardial depression, vasodilation and fluid loss may cause shock with hypotension, electrolyte disturbances and acute renal failure. Increased blood pressure can also result from antimony poisoning. Alterations in pulmonary function and other effects including chronic bronchitis, chronic emphysema, inactive tuberculosis, pleural adhesions, and irritation can result from inhalation of antimony. Antimony poisoning can also lead to pneumoconiosis. Health Effects: Dermal exposure to antimony can cause antimony spots (papules and pustules around sweat and sebaceous glands).Exposure can also occur through dermal or skin contact (L741). Uses/Sources: Breathing air, drinking water, and eating foods that contain antimony.Some of the fecal antimony may represent unabsorbed antimony that is cleared from the lung via mucociliary action into the esophagus to the gastrointestinal tract. Antimony is excreted via the urine and feces. It is not known if these interactions are toxicologically significant. Antimony can covalently interact with sulfhydryl groups and phosphate, as well as numerous reversible binding interactions with endogenous ligands (e.g., proteins). Antimony is a metal and, therefore, does not undergo catabolism. Blood is the main vehicle for the transport of absorbed antimony to various tissue compartments of the body. The adrenal glands, lung, large intestine, trachea, cerebellum, and kidneys also contain relatively high levels of antimony. The hair and skin contain the highest levels of antimony.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |